Biophysics in cancer: The relevance of drug-membrane interaction studies

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Alves, AC (Autor) Outra; Ribeiro, D (Autor) Outra; Nunes, C (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Biochimica et Biophysica Acta: Biomembranes

Vol. 1858

Páginas: 2231-2244

ISSN: 0005-2736

Editora: Elsevier

Indexação

ISI Web of Knowledge - 28 Citações

Scopus - 78 Citações

Outras Informações

ID Authenticus: P-00K-MGZ

DOI: 10.1016/j.bbamem.2016.06.025

Abstract (EN): Lipidomics has been proving that membrane lipids play a crucial role in several cell functions and are involved in several pathologies, including cancer. In fact, beyond a scaffold where proteins and other components are embedded, the cell membrane can also act as a barrier or a target for anticancer drugs. From this point of view, the development of new chemotherapeutic agents should also take into account the role of the membrane in their activity. This Review aims to highlight the importance of anticancer drug-membrane interactions as a powerful strategy to improve cancer therapy. Biophysical techniques emerge, therefore, as essential tools to unveil such interactions.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14