Biophysics in cancer: The relevance of drug-membrane interaction studies

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Alves, AC (Author) Other; Ribeiro, D (Author) Other; Nunes, C (Author) Other; Salette Reis (Author) FFUP

Journal

Title: Biochimica et Biophysica Acta: Biomembranes

Vol. 1858

Pages: 2231-2244

ISSN: 0005-2736

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 78 Citations

Other information

Authenticus ID: P-00K-MGZ

DOI: 10.1016/j.bbamem.2016.06.025

Abstract (EN): Lipidomics has been proving that membrane lipids play a crucial role in several cell functions and are involved in several pathologies, including cancer. In fact, beyond a scaffold where proteins and other components are embedded, the cell membrane can also act as a barrier or a target for anticancer drugs. From this point of view, the development of new chemotherapeutic agents should also take into account the role of the membrane in their activity. This Review aims to highlight the importance of anticancer drug-membrane interactions as a powerful strategy to improve cancer therapy. Biophysical techniques emerge, therefore, as essential tools to unveil such interactions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14