Folate-targeted nanostructured lipid carriers for enhanced oral delivery of epigallocatechin-3-gallate

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Granja, A (Autor) Outra; Vieira, AC (Autor) Outra; Chaves, LL (Autor) Outra; Nunes, C (Autor) Outra; Neves, AR (Autor) Outra; Pinheiro, M (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Food Chemistry

Vol. 237

Páginas: 803-810

ISSN: 0308-8146

Editora: Elsevier

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 24 Citações

Outras Informações

ID Authenticus: P-00N-G7E

DOI: 10.1016/j.foodchem.2017.06.019

Abstract (EN): The well-known pleiotropic health benefits of green tea are mainly attributed to epigallocatechin-3-gallate (EGCG), a polyphenolic compound from the group of catechins. EGCG's poor stability and intestinal permeability, however, can strongly impair its biological activities. In this work, EGCG-loaded nanostructured lipid carriers (NLC) functionalized with folic acid were optimized through a Box-Behnken design intended to provide an enhanced oral absorption and increased bioavailability of EGCG. Size, zeta potential and encapsulation efficiency (EE) of the produced spherical nanoparticles were evaluated. NLC were further characterized by Differential Scanning Calorimetry (DSC). An in vitro release study in simulated gastric and intestinal fluids was conducted and the storage stability of the nanoparticles was evaluated over a period of 8 weeks. The overall results demonstrated the suitability of the developed formulation for the oral delivery of EGCG and its potential for applications in food industry.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8