Celiac disease diagnosis and gluten-free food analytical control

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2010

Autores

Marta Maria P D Pereira da Silva Neves (Autor) Outra; Maria B Begona Gonzalez Garcia (Autor) Outra; Hendrikus Petrus A Antonius Nouws (Autor) Outra; Cristina Delerue Matos (Autor) Outra; Alice Santos Silva (Autor) FFUP; Agustin Costa Garcia (Autor) Outra

Revista

Título: Analytical and Bioanalytical Chemistry

Vol. 397 Nº 7

Páginas: 1743-1753

ISSN: 1618-2642

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 24 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-003-50K

DOI: 10.1007/s00216-010-3753-1

Abstract (EN): Celiac disease (CD) is an autoimmune enteropathy, characterized by an inappropriate T-cell-mediated immune response to the ingestion of certain dietary cereal proteins in genetically susceptible individuals. This disorder presents environmental, genetic, and immunological components. CD presents a prevalence of up to 1% in populations of European ancestry, yet a high percentage of cases remain underdiagnosed. The diagnosis and treatment should be made early since untreated disease causes growth retardation and atypical symptoms, like infertility or neurological disorders. The diagnostic criteria for CD, which requires endoscopy with small bowel biopsy, have been changing over the last few decades, especially due to the advent of serological tests with higher sensitivity and specificity. The use of serological markers can be very useful to rule out clinical suspicious cases and also to help monitor the patients, after adherence to a gluten-free diet. Since the current treatment consists of a life-long gluten-free diet, which leads to significant clinical and histological improvement, the standardization of an assay to assess in an unequivocal way gluten in gluten-free foodstuff is of major importance.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11