Dual effect of red wine on liver redox status: a concise and mechanistic review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Paula Silva (Autor) ICBAS; Eduarda Fernandes (Autor) FFUP; Felix Carvalho (Autor) FFUP

Revista

Título: Archives of Toxicology

Vol. 89

Páginas: 1681-1693

ISSN: 0340-5761

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 9 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-00G-5V3

DOI: 10.1007/s00204-015-1538-1

Abstract (EN): Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotective effects, mainly due to the antioxidant effect of resveratrol, one of its polyphenolic compounds. In this paper, the potential molecular mechanisms through which the protective effects of resveratrol counteract the oxidative effect of ethanol and the way as this dual effect impacts liver oxidative stress are reviewed. Mechanistic evaluation of modulation of oxidative signaling pathways by ethanol and resveratrol may explain the pathogenesis of various liver diseases and ultimately to disclose possible pharmacological therapies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13