Voltammetric quantification of fluoxetine: Application to quality control and quality assurance processes

• Type: Article in International Scientific Journal
• Date: 2006

Authors

lencastre, rui p. (Author) Other; matos, cristina d. (Author) Other; garrido, jorge (Author) Other; borges, fernanda (Author) FFUP; garrido, e. manuela (Author) Other

Journal

Title: Journal of Food and Drug Analysis

Vol. 14

Pages: 242-246

ISSN: 1021-9498

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 27 Citations

Scopus - 29 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry

Other information

Authenticus ID: P-004-HKK

Abstract (EN): The oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte. Under optimized conditions, a linear response was obtained in the range 10 to 16 mu M with a detection limit of 1.0 mu M. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of fluoxetine in pharmaceutical formulations. The results were statistically compared with those obtained by the reference high-performance liquid chromatographic method. No significant differences were found between the methods.

Language: English

Type (Professor's evaluation): Scientific