Cannabis consumption in reproductive function and teratogenicity

• Type: Chapter or Part of a Book
• Date: 2023

Authors

Sa, SI (Author) FMUP; Fonseca, M (Author) Other

Book

Title: Cannabis Use, Neurobiology, Psychology, and Treatment

Pages: 541-553

ISBN: 978-032389862-1; 978-032390140-6

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00Y-V66

DOI: 10.1016/b978-0-323-89862-1.00035-0

Abstract (EN): Cannabis is the most frequently used illicit drug worldwide. Recent authorization of cannabis use in many countries, allied with increasing social and medical acceptance, is rapidly changing drug use prevalence. Notwithstanding variations in public perceptions about the risks of cannabis to reproductive function, cannabis regular use is rapidly growing among young adults and pregnant women. Cannabinoid¿s exposure can have potentially negative effects on reproductive health. Moreover, its use is often associated with alcohol, tobacco, and other illicit substances, which increases the risk of damaging effects. Cannabinoids impact hypothalamic-pituitary-gonadal axis and disturbs the regulation of several hormones that are crucial to the reproductive function. As a consequence, important reproductive events like folliculogenesis, ovulation, and sperm maturation are affected. In addition, both cannabinoid receptors are expressed in reproductive tissues and human gametes, which expands the potential detrimental actions of cannabinoids. Nevertheless, most evidence of cannabis hazards remains on preclinical studies. Here, we introduce the most prominent clinical evidence about cannabis consumption in human reproductive potential and teratogenicity. © 2023 Elsevier Inc. All rights reserved.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12