Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Moreira Pinto, B (Author) Other; Costa, L (Author) Other; Felgueira, E (Author) Other; Fonseca, BM (Author) Other; Rebelo, I (Author) FFUP

Journal

Title: Antioxidants

Vol. 10

Final page: 561

ISSN: 2076-3921

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00T-RC5

DOI: 10.3390/antiox10040561

Abstract (EN): Resveratrol is a phytoalexin present in plant-derived foods, including grape's skin, cocoa, and peanuts. Evidence suggests that it has beneficial effects on human health because of its antioxidant properties. However, there is limited knowledge about the part played by resveratrol in ovarian function. In this paper, the influence of resveratrol on granulosa cells (GC) was evaluated. In addition to being the main estradiol producers, GC are in direct contact with the oocyte, playing a fundamental role in its growth and development. The cell line COV434 and human granulosa cells (hGC), obtained from women undergoing assisted reproductive technology (ART), were used. GC were treated with resveratrol (0.001-20 mu M) at different times (24-72 h). Low concentrations of this compound suggest a protective role, as they tend to reduce ROS/RNS formation after inducement of stress. On the contrary, high concentrations of resveratrol affect GC viability and steroidogenic function. As it may act as a direct modulator of GC oxidative balance, this work may help to clarify the impact of resveratrol on GC and the usefulness of this antioxidant as adjunct to infertility treatments.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13