New Data for Nebivolol after In Silico PK Study: Focus on Young Patients and Dosage Regimen

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Marques, L (Author) Other; Costa, B (Author) Other; Nuno Vale (Author) FMUP

Journal

Title: Pharmaceutics

Vol. 14 No. 3

Final page: 1911

ISSN: 1999-4923

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00X-4RE

DOI: 10.3390/pharmaceutics14091911

Abstract (EN): Nebivolol (NEB) is a highly selective beta 1 receptor antagonist with a distinct pharmacological profile. This drug is approved for the treatment of hypertension in the US, and hypertension and heart failure in Europe. Here, we review observations based on age dependence and explore new drug regimens with in-silico studies, to achieve better efficacy and safety. The clinical data were obtained from six published literature reports. Then the data were used for model building, evaluation, and simulation. A two-compartment model with first-order absorption, lag time, linear elimination, and the following covariates: age and genotype were the ones best describing our population. Simulation of different dose regimens resulted in an increase chance of efficacy and safety when the dose regimen was altered to 6 mg every 36 h. It is worth noting that our population in this study constituted of young and healthy individuals. Studies regarding the effects of NEB according to age are scarce; however, they are needed to further improve efficacy and safety, and reduce adverse effects.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14