Skin tests and challenge-based drug allergy diagnosis: A retrospective study of patients with confirmed drug allergy

• Type: Other Publications
• Date: 2019

Authors

Pereira, AM (Author) FMUP; Couto, M (Author) Other; Pereira, M (Author) Other; Araujo, L (Author) FMUP; Fonseca, J (Author) FMUP

Other information

Authenticus ID: P-00Q-YJD

DOI: 10.23822/eurannaci.1764-1489.107

Abstract (EN): Objectives. To describe clinical manifestations and performed diagnostic workup, focusing on drug challenge tests (DCT), in patients with drug allergy. Methods. Retrospective study including all patients with skin tests (STs) or DCT-based drug allergy diagnosis between 01/2014-06/2018 in a Portuguese allergy unit. Data were collected from electronic and paper-based clinical records. Results. We had 75 drug allergy diagnoses. Most index reactions were mild and ¿ 1 hour after drug intake. Fifty-nine (78%) diagnoses were based on DCTs, all based on multistep protocols with ¿ 3 predicted steps. Only 10% of the DCT were positive during up-dosing; timing and severity of the index reaction predicted DCT interruption during up-dosing. Conclusions. Most drug allergy diagnoses were based on multistep DCT. The identified predictors of DCT interruption during up-dosing can support the development of more personalized DCTs protocols.

Language: English

Type (Professor's evaluation): Scientific