Small Molecules of Marine Origin as Potential Anti-Glioma Agents

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Alves, A (Author) Other; Paulo Costa (Author) FFUP; Pinto, M (Author) Other; Ferreira, D (Author) Other; Marta Correia da Silva (Author) FFUP

Journal

Title: Molecules

Vol. 26 No. 17

Final page: 2707

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00T-Y22

DOI: 10.3390/molecules26092707

Abstract (EN): Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21