Impact of nanosystems in Staphylococcus aureus biofilms treatment

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Pinto, RM (Author) Other; Lopes de Campos, D (Author) Other; Martins, MCL (Author) Other; Van Dijck, P (Author) Other; Nunes, C (Author) Other; Salette Reis (Author) FFUP

Journal

Title: FEMS Microbiology Reviews

Vol. 43

Pages: 622-641

ISSN: 0168-6445

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 32 Citations

Other information

Authenticus ID: P-00R-SN2

DOI: 10.1093/femsre/fuz021

Abstract (EN): Staphylococcus aureus (S. aureus) is considered by the World Health Organization as a high priority pathogen for which new therapies are needed. This is particularly important for biofilm implant-associated infections once the only available treatment option implies a surgical procedure combined with antibiotic therapy. Consequently, these infections represent an economic burden for Healthcare Systems. A new strategy has emerged to tackle this problem: for small bugs, small particles. Here, we describe how nanotechnology-based systems have been studied to treat S. aureus biofilms. Their features, drawbacks and potentialities to impact the treatment of these infections are highlighted. Furthermore, we also outline biofilm models and assays required for preclinical validation of those nanosystems to smooth the process of clinical translation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 20