Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Isabel Burguete, MI (Author) Other; Galindo Rosales, FJ (Author) Other; Gavara, R (Author) Other; Luis, SV (Author) Other; Moreno, M (Author) Other; Thomas, P (Author) Other; Russell, DA (Author) Other

Journal

Title: Photochemical & Photobiological Sciences

Vol. 8

Pages: 37-44

ISSN: 1474-905X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 29 Citations

Other information

Authenticus ID: P-005-5X7

DOI: 10.1039/b810921d

Abstract (EN): Photogeneration of singlet oxygen ((1)O(2)) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8