Characterization of gelatin and chitosan scaffolds cross-linked by addition of dialdehyde starch

• Type: Article in International Scientific Journal
• Date: 2018

Authors

B. Kaczmarek (Author) Other; A. Sionkowska (Author) Other; Fernando Mendes Monteiro (Author) FEUP; A. Carvalho (Author) Other; K. Lukowicz (Author) Other; A. M. Osyczka (Author) Other

Journal

Title: Biomedical Materials (Bristol)

Vol. 13 No. 1

ISSN: 1748-6041

Publisher: Institute of Physics Publishing

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 12 Citations

INSPEC

Other information

Authenticus ID: P-00N-B84

DOI: 10.1088/1748-605x/aa8910

Abstract (EN): In this study the influence of the addition of dialdehyde starch on the properties of scaffolds based on gelatin and chitosan obtained by the freeze-drying method was investigated. In addition, the adhesion and proliferation of human osteosarcoma SaOS-2 cells on the obtained scaffolds was examined. Chitosan and gelatin were mixed in different weight ratios (75/25, 50/50, 25/75) with 1, 2 and 5 wt% addition of dialdehyde starch. The obtained scaffolds were subjected to mechanical testing, infrared spectroscopy, swelling measurements, low-pressure porosimetry and zeta potential measurement. Internal material structures were observed by scanning electron microscopy. The results showed that the cross-linking process occurred after the addition of dialdehyde starch and resulted in increased mechanical strength, swelling properties, zeta potential and porosity of studied materials. The attachment of SaOS-2 cells to all modified materials was better compared to an unmodified control and the proliferation of these cells was markedly increased on modified scaffolds.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11