Interaction of local anaesthetics with other antifungal agents against pathogenic Aspergillus

• Type: Article in International Scientific Journal
• Date: 2006

Authors

rodrigues, ag (Author) FMUP; Ricardo Araujo (Author) Other; pina-vaz, c (Author) FMUP

Journal

Title: International Journal of Antimicrobial Agents

Vol. 27

Pages: 339-343

ISSN: 0924-8579

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-004-MF3

DOI: 10.1016/j.ijantimicag.2005.11.011

Abstract (EN): Aspergillus spp. are responsible for ail increasing number of fungal infections in immunocompromised and transplant patients. Local anaesthetics (LAs) are growth inhibitors of bacteria and yeasts. Subinhibitory concentrations of the LAs lidocaine and bupivacaine blocked the germination of Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger whilst also showing a positive interaction in vitro with the antifungal activity of amphotericin B. itraconazole and caspofungin and a negative interaction with voriconazole. At higher concentrations, both LAs present fungicidal activity against resting conidia owing to cell membrane lesions. Verapamil, nifedipine and lanthanum produced a similar inhibitory effect on conidia germination. Calcium chloride reverted the inhibitory effect of verapamil and LAs. This study highlights that drug interactions may affect the clinical efficacy of antifungals. either promoting or limiting their action.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5