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BRAFV600E mutation in papillary thyroid carcinoma: A potential target for therapy?

Title
BRAFV600E mutation in papillary thyroid carcinoma: A potential target for therapy?
Type
Another Publication in an International Scientific Journal
Year
2009
Authors
Soares, P
(Author)
FMUP
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Preto, A
(Author)
Other
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Sobrinho Simoes, M
(Author)
FMUP
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Journal
Vol. 4
Pages: 467-480
ISSN: 1744-6651
Publisher: Taylor & Francis
Indexing
Publicação em ISI Web of Knowledge ISI Web of Knowledge
Publicação em Scopus Scopus - 0 Citations
Other information
Authenticus ID: P-007-RJ5
Abstract (EN): This article reviews the therapeutic significance of the close genotype-phenotype association in papillary thyroid carcinoma, namely regarding the association between genetic alterations in RET, BRAF or RAS genes and the histopathological variants of papillary thyroid carcinoma. Based upon the aforementioned review on morphology and molecular pathology, the most recent prognostic and therapeutic data are reviewed and the role of targeted therapies, namely those interfering with BRAF-activated pathways are discussed, which may play a role in the treatment of patients with papillary thyroid carcinoma unresponsive to radioactive iodine. © 2009 Expert Reviews Ltd.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 14
Documents
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