Translating endoplasmic reticulum biology into the clinic: a role for ER-targeted natural products?

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

David M Pereira (Author) FFUP; Patricia Valentao (Author) Other; Georgina Correia da Silva (Author) FFUP; Natercia Teixeira (Author) FFUP; Paula B Andrade (Author) FFUP

Journal

Title: Natural Product Reports

Vol. 32

Pages: 705-722

ISSN: 0265-0568

Publisher: Royal Society of Chemistry

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 20 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-00A-DC2

DOI: 10.1039/c4np00102h

Abstract (EN): ER stress has been identified as a hallmark, and sometimes trigger, of several pathologies, notably cancer, inflammation and neurodegenerative diseases like Alzheimer's and Parkinson's. Among the molecules described in literature known to affect ER function, the majority are natural products, suggesting that natural molecules may constitute a significant arsenal of chemical entities for modulating this cellular target. In this review, we will start by presenting the current knowledge of ER biology and the hallmarks of ER stress, thus paving the way for presenting the natural products that have been described as being ER modulators, either stress inducers or ER protectors. The chemistry, distribution and mechanism of action of these compounds will be presented and discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18