New titanium and titanium/hydroxyapatite coatings on ultra-high-molecular-weight polyethylene-in vitro osteoblastic performance

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Silva, MA (Author) Other; Gomes, PS (Author) FMDUP; Vila, M (Author) Other; Lopes, MA (Author) FEUP; Santos, JD (Author) FEUP; Silva, RF (Author) Other; Fernandes, MH (Author) FMDUP

Journal

Title: Biomedical Materials (Bristol)

Vol. 5 No. 3

Final page: 035014

ISSN: 1748-6041

Publisher: Institute of Physics Publishing

Indexing

ISI Web of Knowledge - 5 Citations

ISI Web of Science

Scopus - 8 Citations

Pubmed / Medline

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-003-5W2

DOI: 10.1088/1748-6041/5/3/035014

Abstract (EN): The development of optimized hip joint materials is one of the most challenging opportunities in prosthetic technologies. In current approaches, ultra-high-molecular-weight polyethylene (UHMWPE) has been a favorite material for the acetabular component and, regarding the cementless technique, several coating options may be considered to contain and stabilize bearing surfaces and establish an improved interface with bone. In this work, newly developed constructs of UHMWPE coated with either commercially pure titanium (cpTi-UHMWPE), by DC magnetron sputtering, or with commercially pure titanium and hydroxyapatite (cpTi/HA-UHMWPE), by DC/RF magnetron co-sputtering, have been prepared and biologically characterized with human bone marrow-derived osteoblastic cultures. The cpTi-UHMWPE samples allowed a high cell growth and the expression of the complete osteoblastic phenotype, with high alkaline phosphatase activity, expression of osteogenic-associated genes and evident cell-mediated mineralization of the extracellular matrix. In comparison, the cpTi/HA-UHMWPE samples reported lower cell proliferation but earlier cell-mediated matrix mineralization. Accordingly, these newly developed systems may be suitable candidates to improve the osteointegration process in arthroplastic devices; nevertheless, further biological evaluation should be conducted.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9