Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Carla Fernandes (Author) FFUP; Carraro, ML (Author) Other; Ribeiro, J (Author) Other; Araujo, J (Author) Other; Tiritan, ME (Author) Other; Pinto, MMM (Author) Other

Journal

Title: Molecules

Vol. 24

Final page: 791

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 27 Citations

Scopus - 26 Citations

Other information

Authenticus ID: P-00Q-BSC

DOI: 10.3390/molecules24040791

Abstract (EN): Many naturally occurring xanthones are chiral and present a wide range of biological and pharmacological activities. Some of them have been exhaustively studied and subsequently, obtained by synthesis. In order to obtain libraries of compounds for structure activity relationship (SAR) studies as well as to improve the biological activity, new bioactive analogues and derivatives inspired in natural prototypes were synthetized. Bioactive natural xanthones compromise a large structural multiplicity of compounds, including a diversity of chiral derivatives. Thus, recently an exponential interest in synthetic chiral derivatives of xanthones (CDXs) has been witnessed. The synthetic methodologies can afford structures that otherwise could not be reached within the natural products for biological activity and SAR studies. Another reason that justifies this trend is that both enantiomers can be obtained by using appropriate synthetic pathways, allowing the possibility to perform enantioselectivity studies. In this work, a literature review of synthetic CDXs is presented. The structures, the approaches used for their synthesis and the biological activities are described, emphasizing the enantioselectivity studies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 36