Project: 2022.05543.PTDC

Project name:	Smart4Vir - Smart surfactant-based nanovectors for RNA anti-viral therapeutics
Project code:	2022.05543.PTDC
Proposing institution/Lead promoter/Coordinating entity:	Faculdade de Ciências da Universidade do Porto
Partner(s)/Co-promoter(s)/Participating institution(s):	REQUIMTE - Rede de Química e Tecnologia - Associação (REQUIMTE-P); Universidade do Minho
Start date:	2023-02-01
Completion date:	2026-01-31

Eligible Cost of the Project

Total Eligible Cost:	249.189,47 EUR
Eligible Cost in the University of Porto:	108.082,62 EUR
Faculdade de Ciências da Universidade do Porto:	108.082,62 EUR

Total Financial Support

Orçamento de Estado:

249.189,47 EUR

Financial Support to the University of Porto

Total of the University of Porto:	108.082,62 EUR
Nacional/Regional \| Orçamento de Estado \| Faculdade de Ciências da Universidade do Porto:	108.082,62 EUR

Objectives, activities and expected/achieved results

This project is expected to lead to the successful development of formulation of a few RNA nanovectors with suitable features for an effective in vitro delivery,
namely with respect to complexation efficiency, loading ability, stability and stimuli-sensitivity. Given the versatility of the novel surfactants, and the level of
expertise of the team, we are confident on the feasibility of such outcomes. At a fundamental level, we can undertake a global analysis of all key physicochemical
parameters (molecular and physiological) leading to successful nanovectors and the possibility for even further enhancements.
Besides seeking scientific outputs (papers, theses and communications), this project has potential to lead to effective RNA therapeutic nanovectors, at the in
vitro and proof-of-concept level. A patent registration is expected and we may also seek the interest from companies in the medical area. Concomitantly, this
project involves the training of highly qualified human capital in cutting edge areas (organic synthesis, colloid chemistry, nanomedicine), which is important to
foster the national scientific community and the industrial sectors.

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