Drug Design and Sustainable Synthesis of Drugs

Code:

MI224181

Acronym:

POSFARM

Keywords
Classification	Keyword
OFICIAL	Physical Sciences

Instance: 2025/2026 - 1S

Active?	Yes
Responsible unit:	Organic and Pharmaceutical Chemistry Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	26	MICF - Transition Study Plan 2023/24 - 2024/25 - 2025/26	4	-	1,5	13	40,5

Teaching language

Portuguese

Objectives

The general objective of this curricular unit is for the student to get in touch with the various strategies/methodologies for planning and sustainably obtaining drugs through a Project-based learning model. The Student, having acquired a set of essential knowledge to follow the evolution that the process of discovering and obtaining drugs has undergone in the mandatory curricular units, in this curricular unit must develop a critical spirit to find the solution to a problem related to the theme and the capacity for adequate expression, as well as argumentation through the preparation of reports, presentation and discussion of a solution to a problem.

The existence of the curricular unit of Planning and Sustainable Procurement of Pharmaceuticals is justified by the need to complement the content of the course units of Pharmaceutical Chemistry, generalist by nature, with a set of essential knowledge that allows students to deepen their understanding of drug planning and synthesis methodologies while also developing sustainable-by-design thinking.

This curricular unit, in addition to consolidating and integrating knowledge related to various strategies/methodologies for sustainable drug planning and sourcing, is crucial in promoting the integration of sustainability into the learning process. The concepts of green chemistry, the circular economy, and the relevance of the Sustainable Development Goals (SDGs) are topics covered in the course, which students integrate into the various stages of their project development.

 

 

Learning outcomes and competences

The student should obtain:

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

It is assumed students have the basic knowledge provided by the subjects: Organic Chemistry I, Organic Chemistry II, Pharmaceutical Chemistry I, Biochemistry, Pharmacology and Instrumental Analysis Methods.

 

 

Program

 

 

 

Application of tools in use to the discovery and sustainably design of new drugs in a project with a PBL modality:

 

- The resolution of problems that could be faced in planning and obtaining drugs

- The preparation and presentation by the students of a "problem" on planning a drug

 

 

 

 

 

Mandatory literature

Pinto Madalena M. M. 340; Manual de trabalhos laboratoriais de química orgânica e farmacêutica. ISBN: 978-972-757-750-7

Teaching methods and learning activities

Preparation, monitored by Professors, and presentation by Students of a project (problem-based learning) related to the discovery and/or sustainably obtaining of new drugs.

- In silico methods and literature search to predict/support proposed results.
The professors in charge will be available in the schedule previously announced at the beginning of the semester and by appointment.

 

keywords

Physical sciences > Chemistry > Organic chemistry
Physical sciences > Chemistry > Computational chemistry
Health sciences > Pharmacological sciences > Pharmacy
Physical sciences > Chemistry > Combinatorial chemistry

Evaluation Type

Distributed evaluation without final exam

Assessment Components

designation	Weight (%)
Prova oral	50,00
Trabalho prático ou de projeto	50,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Apresentação/discussão de um trabalho científico	5,00
Elaboração de projeto	50,00
Estudo autónomo	10,00
Frequência das aulas	25,00
Trabalho escrito	10,00
Total:	100,00

Eligibility for exams

 

 

Calculation formula of final grade

- Reports and Presentation and discussion of a "problem-based learning": factor 100%.

 

Internship work/project

not applicable

Special assessment (TE, DA, ...)

Students that by law do not need to attend the practical classes, and do not have frequency in these classes must perform a final written exam in date according to the academic calendar
Students with assessments obtained in previous years may give up of the continuous assessment (must contact the Responsible UC) and perform new evaluation; otherwise,  must perform a final written exam in date according to the academic calendar

Classification improvement

Students will have to make a final examination on the methodologies used in the project.