Pharmacology II

Code:

MI074132

Acronym:

FCOL2

Keywords
Classification	Keyword
OFICIAL	Health Sciences

Instance: 2012/2013 - 1S

Active?	Yes
Web Page:	http://moodle.up.pt/course/view.php?id=838
Responsible unit:	Pharmacology Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	215	Official Curriculum	4	-	6,5	65	175,5

Teaching language

Portuguese

Objectives

Objectives
It is intended that the student understand the most relevant aspects related to the mechanism of action, pharmacodynamic and pharmacokinetic properties and the most frequent adverse reactions of the most important drugs in each therapeutic classes.
The laboratory classes of this discipline aim at developing and improving the scientific skils in the design and performance of experimental procedures in pharmacological assays using in vitro preparations (isolated tissues) and the analysis and discussion of experimental data.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Students should have knowledge about the workings of different organ systems that make up the human body and its functional relationships.

Program

Imunopharmacology

1 Introduction to imunopharmacology and inflammation
1.1. Signs and characteristics of the inflammatory response
1.2. Mechanisms of host defence: cells and mediators
1.3. Eicosanoides and inflammatory response: role of prostaglandins, tromboxanes, leukotrienes and related compounds

2 Drugs used in inflammation
2.1 Non steroidal anti-inflammatory drugs (NSAIDs)
2.2 Corticosteroids
2.3 Disease-modifying antirheumatic drugs
2.4 Drugs used in gout

3 Histamine Pharmacology
3.1 Role of histamine in inflammation and allergic reactions
3.2 H1 receptor antagonists
3.3 Histamine and regulation of gastric acid secretion
3.4 Drugs used in peptic ulcer disease
3.4.1 H2 receptor antagonists
3.4.2 Proton pump inhibitors
3.4.3 Antacids
3.4.4 Mucosal protective agents

4 Drugs used in Asthma and Chronic Pulmonary Obstructive Disorders
4.1 Corticosteroids
4.2 -Selective adrenoceptor agonists
4.3 Methylxanthines
4.4 Other drugs with prophylactic effect on bronchospasm: leukotriene antagonists, inhibitors of mastocite degranulation, muscarinic antagonists and anti-IgE monoclonal antibodies

Cardiovascular Pharmacology
1. Pharmacology of Cardicac rhythm
1.1. Pathophysiology of Cardiac Electric Disfunction
1.2. Drug classes
1.2.1.General mechanisms of action
1.2.2. Antiarhythmic classes
2. Pharmacology da Cardiac Contractility
2.1. Physiology e Pathophysiology of Contractile dysfunction
2.2. Drug classes
2.2.1. Cardiac glucosides
2.2.2. Beta-adrenergic agents
2.2.3 Phosphodiesterase inhibitors
3. Pharmacology of Volume Regulaion
3.1. Physiology of Volume Regulaion and Pathophysiology of Edema
3.2. Drug classes
3.2.1. Renin-angiotensin system Inhibitors
3.2.2. Diuretics
3.2.3. Other agents
4. Pharmacology of Vascular Tone
4.1. Physiology of the vascular smooth muscle contraction/relaxation
4.2. Drug classes
4.2.1. Nitrates e sodium nitroprusside
4.2.2. Calcium channel blockers
4.2.3.Renin-angiotensin system Inhibitors
4.2.4. Other agents
5. Pharmacology of Hemostase and Thrombose
6. Pharmacology of Lipoprotein and Cholesterol Metabolism
7. Integrative Cardiovascular Pharmacology
7.1. Hypertension
7.2. Congestive Heart Failure
7.3. Isquemic Heart Disease

Endocrine Pharmacology
1. Pharmacology of Thyroid Gland
2. Pharmacology of Reproduction
3. Pharmacology of Endocrine Pancreas

Mandatory literature

Katzung B.G.; Basic and Clinical Pharmacology, 10th Ed. McGrawHill, 2007. ISBN: ISBN-978-007-110441-8
Rang H.P., Dale M.M., Ritter J.M., Flower R.J., Henderson G.; Rang and Dale's Pharmacology, 7th Ed. Elsevier , 2012. ISBN: ISBN-13 978-7020-3471-8

Teaching methods and learning activities

The pharmacoloy classes has two components:
Lectures and experimental classes (laboratory) classes.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	65,00
	Trabalho escrito	10,00
	Trabalho escrito	40,00
	Exame	80,00
	Total:	-	0,00

Special assessment (TE, DA, ...)

Workers students and ERASMUS Students or may waive the laboratory evaluation component.  In this case they will be evaluated only in a final exam that will cover matters of theory and laboratory, including practical cases solved by peers during the semester, and will have a price of 20. ERASMUS Students will have to attend laboratory classes and the workers students and should notify their decision to the responsible of teh discipline, early in the semester.