Three new jatrophane-type diterpenes from Euphorbia pubescens

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Valente, C (Autor) Outra; Ferreira, MJU (Autor) Outra; Abreu, PM (Autor) Outra; Pedro, M (Autor) Outra; Cerqueira, F (Autor) Outra; Nascimento, MSJ (Autor) FFUP

Revista

Título: Planta Medica

Vol. 69

Páginas: 361-366

ISSN: 0032-0943

Editora: Thieme

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 18 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-H9J

DOI: 10.1055/s-2003-38875

Abstract (EN): Three new macrocyclic jatrophane diterpene polyesters, named pubescenes A (1), B (2), and C (3), and the known compounds indole-3-aldehyde and scopoletin have been isolated and characterised from the whole dried plant of Euphorbia pubescens. The structures of the new compounds were established by spectroscopic means including 2D-NMR techniques such as COSY, HMQC, HMBC and NOESY experiments. Compounds 1-3 were evaluated for their in vitro effect on the growth of three human cancer cell lines MCF-7 (breast), NCI-H460 (lung) and SF-268 (CNS) as well as for their capacity to interfere with the proliferation of human peripheral blood lymphocytes. They exhibited a moderate growth inhibitory effect on the cancer cell line NCI-H460. No effect was observed on the mitogenic response of human lymphocytes to PHA.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6