4 '-Methoxy-2-styrylchromone a novel microtubule-stabilizing antimitotic agent

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Joana Marinho (Autor) Outra; Madalena Pedro (Autor) Outra; Diana C G A Pinto (Autor) Outra; Artur M S Silva (Autor) Outra; Jose A S Cavaleiro (Autor) Outra; Claudio E Sunkel (Autor) ICBAS; Maria Sao Jose Nascimento (Autor) FFUP

Revista

Título: Biochemical Pharmacology

Vol. 75 Nº 4

Páginas: 826-835

ISSN: 0006-2952

Editora: Elsevier

Indexação

ISI Web of Knowledge - 35 Citações

Scopus - 39 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-004-1G5

DOI: 10.1016/j.bcp.2007.10.014

Abstract (EN): 4 '-Methoxy-2-styrylchromone, a new synthetic chromone was identified as a selective proliferation inhibitor of human tumor (MCF-7 and NCI-H460) cell lines than to non-tumor cells (MRC-5). The antiproliferative activity of this chromone was also extensive to peripheral human lymphocytes. 4 '-Methoxy-2-styrylchromone was found to block tumor cells in the G(2)/M phase of the cell cycle. The G(2)/M arrest of NCI-H460 cells was dose- and time-dependent, reaching a maximum after 12-h treatment while MCF-7 cells reached the maximum value of G2/M accumulation only after a 24-h treatment. Chromone-treated cells evidenced a high frequency of cells in prometaphase, indicating progression beyond G(2) and arrest early in mitosis. This mitotic arrest was associated with abnormal mitotic spindles characterized by the formation of a monopolar structure, suggesting that the chromone interferes with microtubules. The results of an in vitro tubulin polymerization assay showed that this chromone stabilizes microtubules in a manner similar to paclitaxel.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10