Sartoryglabrins, Analogs of Ardeemins, from Neosartorya glabra

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Anake Kijjoa (Autor) ICBAS; Sonia Santos (Autor) Outra; Tida Dethoup (Autor) Outra; Leka Manoch (Autor) Outra; Ana Paula Almeida (Autor) Outra; Maria Helena Vasconcelos (Autor) FFUP; Artur Silva (Autor) Outra; Luis Gales (Autor) ICBAS; Werner Herz (Autor) Outra

Revista

Título: Natural product communications

Vol. 6

Páginas: 807-812

ISSN: 1934-578X

Editora: SAGE

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 22 Citações

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

Outras Informações

ID Authenticus: P-002-QRV

Abstract (EN): Chemical investigation of a collection of the fungus Neosartorya glabra from Thailand furnished sartoryglabins A-C (1a, 1b and 2) which are analogs of the reverse prenylated indole alkaloids known as (-) ardeemins. Structures of these compounds were established by NMR spectrometry and an X-ray analysis. Sartoryglabins A-C were evaluated for their in vitro growth inhibitory activity on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma). All the compounds exhibited strong to moderate activity against the MCF-7 cell line but weak or no activity against the NCI-H460 and A375-C5 cell lines. Sartoryglabin B was found to exhibit selectivity towards the MCF-7 cell line.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6