High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Pereira, L (Autor) Outra; Richards, M (Autor) Outra; Goios, A (Autor) Outra; Alonso, A (Autor) Outra; Albarran, C (Autor) Outra; Garcia, O (Autor) Outra; Behar, DM (Autor) Outra; Golge, M (Autor) Outra; Hatina, J (Autor) Outra; Al Gazali, L (Autor) Outra; Bradley, DG (Autor) Outra; Macaulay, V (Autor) Outra; Amorim, A (Autor) FCUP

Revista

Título: Genome Research

Vol. 15

Páginas: 19-24

ISSN: 1088-9051

Editora: Cold Spring Harbor Laboratory Press

Indexação

ISI Web of Knowledge - 127 Citações

Scopus - 133 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-000-5S8

DOI: 10.1101/gr.3182305

Abstract (EN): The advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary Studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub-clades within an mtDNA haplogroup, providing a springboard for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to mtDNA haplogroup V, which represents <5% of European mtDNAs. Here we adopted a similar approach to haplogroup H, by far the most common European haplogroup, which at lower resolution displayed a rather uninformative frequency distribution within Europe. Using polymorphism information derived from the growing complete mtDNA sequence database, we sequenced 1580 base pairs of targeted coding-region segments of the mtDNA genome in 649 individuals harboring mtDNA haplogroup H from populations throughout Europe, the Caucasus, and the Near East. The enhanced genealogical resolution clearly shows that sub-clades of haplogroup H have highly distinctive geographical distributions. The patterns of frequency and diversity suggest that haplogroup H entered Europe from the Near East similar to20,000-25,000 years ago, around the time of the Last Glacial Maximum (LGM), and some sub-clades re-expanded from an Iberian refugium when the glaciers retreated similar to15,000 years ago. This shows that a large fraction of the maternal ancestry of modern Europeans traces back to the expansion of hunter-gatherer populations at the end of the last Ice Age.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6