mtDNA phylogeny and evolution of laboratory mouse strains

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Ana Goios (Autor) Outra; Luisa Pereira (Autor) Outra; Molly Bogue (Autor) Outra; Vincent Macaulay (Autor) Outra; Antonio Amorim (Autor) FCUP

Revista

Título: Genome Research

Vol. 17

Páginas: 293-298

ISSN: 1088-9051

Editora: Cold Spring Harbor Laboratory Press

Indexação

ISI Web of Knowledge - 82 Citações

Scopus - 84 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-004-BF0

DOI: 10.1101/gr.5941007

Abstract (EN): Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different mouse subspecies. Although genealogies have been established, female inbred mouse phylogenies remain unexplored. By a phylogenetic analysis of newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common inbred strains descend from the same Mus musculus domesticus female wild ancestor, and suggest that they present a different mitochondrial evolutionary process than their wild relatives with a faster accumulation of replacement substitutions. Our data complement forthcoming results on resequencing of a group of priority strains, and they follow recent efforts of the Mouse Phenome Project to collect and make publicly available information on various strains.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6