PHARMACOLOGICAL CHARACTERIZATION OF POSTSYNAPTIC ALPHA-ADRENOCEPTOR SUBTYPES IN 5 DIFFERENT DOG ARTERIES INVITRO

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 1985

Autores

POLONIA, JJ (Autor) FMUP; PAIVA, MQ (Autor) Outra; GUIMARAES, S (Autor) Outra

Revista

Título: Journal of Pharmacy and Pharmacology

Vol. 37

Páginas: 205-208

ISSN: 0022-3573

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 13 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-WEN

Abstract (EN): The responses of helically cut strips of arteries isolated from five different sites in the body of dogs to relatively selective ¿1- and ¿2-adrenoceptor agonists and the antagonism exerted on these responses by relatively selective ¿1- and ¿2-adrenoceptor blockers have been studied. On all arteries (renal, splenic, cranial mesenteric, jejunal and femoral) phenylephrine was a full agonist whereas UK-13, 304 was a partial agonist causing maximal contractions of 49, 30, 27, 27 and 10% of the maximum, respectively. Phenylephrine was more potent than UK-14,304, being 9 times more potent in the renal artery and up to 42 times more potent in the cranial mesenteric artery. In the dog saphenous vein, where there are both ¿1- and ¿2-adrenoceptors, it has been previously shown that UK-14,304 is 530 times more potent than phenylephrine. Prazosin in low concentrations displaced concentration-response curves for both phenylephrine and UK-14,304 (pA2 values of 8.16-8.43 and 8.13-8.79, respectively) whereas yohimbine was much less potent (pA2 values of 6.53-6.88 and 6.50-7.20, respectively). The results suggest that the ¿-adrenoceptors of all arteries studied are predominantly, if not exclusively, of the ¿1-subtype.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4