Differences in resistance of C57BL/6 and C57BL/10 mice to infection by Mycobacterium avium are independent of gamma interferon

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

appelberg, r (Autor) ICBAS; leal, is (Autor) Outra; pais, tf (Autor) Outra; pedrosa, j (Autor) Outra; florido, m (Autor) Outra

Revista

Título: Infection and Immunity

Vol. 68

Páginas: 19-23

ISSN: 0019-9567

Editora: American Society for Microbiology

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-1NM

Abstract (EN): After infection with a low-virulence strain of Mycobacterium avium, C57BL/6 and C57BL/10 mice had clear differences in the control of the infection in their livers and spleens. This difference in susceptibility was not associated with differences in the H-2 complex. It was dependent on the activity of CD4(+) T cells but unrelated to the ability of these cells to secrete gamma interferon or to the development of delayed-type hypersensitivity responses at 3 weeks of infection. It was associated with lower total numbers of CD4(+) cells present in infected spleens and was related to an earlier induction of protective T cells, as measured by adoptive-transfer assays. These data further strengthen the notion of gamma-interferon-independent mechanisms of protection against mycobacteria.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5