Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Ana S Abreu (Autor) Outra; Elisabete M S Castanheira (Autor) Outra; Maria Joao R P Queiroz (Autor) Outra; Paula M T Ferreira (Autor) Outra; Luis A Vale Silva (Autor) Outra; Eugenia Pinto (Autor) FFUP

Revista

Título: Nanoscale Research Letters

Vol. 6

Páginas: 1-6

ISSN: 1931-7573

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 41 Citações

Scopus - 46 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia dos materiais

Outras Informações

ID Authenticus: P-002-NT6

DOI: 10.1186/1556-276x-6-482

Abstract (EN): A potential antitumoral fluorescent indole derivative, methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2carboxylate, was evaluated for the in vitro cell growth inhibition on three human tumor cell lines, MCF-7 (breast adenocarcinoma), A375-C5 (melanoma), and NCI-H460 (non-small cell lung cancer), after a continuous exposure of 48 h, exhibiting very low GI(50) values for all the cell lines tested (0.25 to 0.33 mu M). This compound was encapsulated in different nanosized liposome formulations, containing egg lecithin (Egg-PC), dipalmitoyl phosphatidylcholine (DPPC), dipalmitoyl phosphatidylglycerol (DPPG), DSPC, cholesterol, dihexadecyl phosphate, and DSPE-PEG. Dynamic light scattering measurements showed that nanoliposomes with the encapsulated compound are generally monodisperse and with hydrodynamic diameters lower than 120 nm, good stability and zeta potential values lower than -18 mV. Dialysis experiments allowed to monitor compound diffusion through the lipid membrane, from DPPC/DPPG donor liposomes to NBD-labelled lipid/DPPC/DPPG acceptor liposomes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6