Voltammetric insights in the transfer of ionizable drugs across biomimetic membranes - Recent achievements

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Rubin Gulaboski (Autor) Outra; Fernanda Borges (Autor) FFUP; Carlos M Pereira (Autor) FCUP; Natalia N D S Cordeiro (Autor) FCUP; Jorge Garrido (Autor) Outra; Fernando F Silva (Autor) FCUP

Revista

Título: Combinatorial Chemistry & High Throughput Screening

Vol. 10

Páginas: 514-526

ISSN: 1386-2073

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 19 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-004-8A1

DOI: 10.2174/138620707782152399

Abstract (EN): The latest results of voltammetric research on the ionic transfer process of ionisable drugs across bare and lipid-modified liquid-liquid interfaces are reviewed. In recent years, two voltammetric methods have been extensively applied to this purpose, i.e. the classical four electrode voltammetry at the interface between two immiscible electrolyte solutions, and the "three-phase electrode." Thus, a brief background of the methodologies and some successful examples of their application are highlighted in this work. Particular attention is given to the ionic transfer kinetics and to the electro-chemical characterization of the drug-membrane interactions between the ionized drugs and lipid-modified interfaces. Future trends in this area are also mentioned in connection with high-throughput assessment of ADMET properties of drugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica