Voltammetric oxidation of drugs of abuse - I. Morphine and metabolites

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Garrido, Jorge M P J (Autor) Outra; Delerue-Matos, C. M Delerue (Autor) Outra; Borges, Fernanda Fernanda M (Autor) FFUP; Macedo, Tice Reis A (Autor) Outra; Oliveira-Brett, A. M. (Autor) Outra

Revista

Título: Electroanalysis

Vol. 16

Páginas: 1419-1426

ISSN: 1040-0397

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 46 Citações

Scopus - 48 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química

Outras Informações

ID Authenticus: P-000-8NQ

DOI: 10.1002/elan.200302966

Abstract (EN): A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of phenolic and tertiary amine groups. It is also possible to verify that a poorly defined peak observable during morphine oxidation is not a consequence of further oxidation of pseudomorphine but due to formation of a dimer during phenolic group oxidation. The results obtained and especially those regarding the formation of a new polymer based on a C-O coupling could be useful for clarifying the discoloration phenomenon occurring during storage of morphine solutions as well as leading to a better understanding of its oxidative metabolic pathways.

Idioma: Inglês

Tipo (Avaliação Docente): Científica