Effects of interleukin-12 in the long-term protection conferred by a Mycobacterium avium subunit vaccine

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

Silva, RA (Autor) Outra; Pais, TF (Autor) Outra; Appelberg, R (Autor) ICBAS

Revista

Título: Scandinavian Journal of Immunology

Vol. 52

Páginas: 531-533

ISSN: 0300-9475

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 9 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Infecções

Outras Informações

ID Authenticus: P-000-YD8

DOI: 10.1046/j.1365-3083.2000.00816.x

Abstract (EN): The effects of the addition of recombinant interleukin (IL)-12 to a mycobacterial subunit vaccine were analyzed in terms of the longevity of the protective immunity generated. BALB/c mice were immunized with culture filtrate proteins from Mycobacterium avium with dimethyl-dioctadecilammonium bromide (DDA) as an adjuvant. This subunit vaccine induced protection against a challenge by M. avium which lasted for at least 6 months while waning with time until 1 year postvaccination. Whereas the addition of IL-12 enhanced the initial protective efficacy of this subunit vaccine during the first 6 months, it accelerated the loss of protective efficacy observed at 1 year postvaccination. These data confirm the adjuvant properties of IL-12 in vaccines against mycobacteria and raise the possibility of late counter-protective untoward effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3