Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Monteiro, C (Autor) FMUP; Deolinda, L (Autor) Outra; Galhardo, V (Autor) FMUP

Revista

Título: Neuroscience Letters

Vol. 398 Nº 3

Páginas: 258-263

ISSN: 0304-3940

Editora: Elsevier

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 5 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Neurociências

Outras Informações

ID Authenticus: P-004-KSY

DOI: 10.1016/j.neulet.2006.01.008

Abstract (EN): Somatosensory deep dorsal horn spinal neurons were previously shown to present in vitro a bistable state of activity in which a fixed firing rate is maintained over prolonged periods in the absence of stimulation. Those periods of enhanced spinal spontaneous discharge may play a role in the genesis or maintenance of hyperalgesic states, where episodes of durable spontaneous pain are commonly reported. Here we show in vivo that a small percentage of deep spinal neurons (4% of the recorded population) are capable of rapidly shifting between low-frequency and high-frequency levels of spontaneous activity. At least one of the transitions between the two states was induced by stimulation of the receptive field, making this an interesting and unique case in which stable firing rates are switched-on or -off by somatosensory stimuli.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6