CIPROFLOXACIN AND NORFLOXACIN SPECTROPHOTOMETRIC DETERMINATION IN A FULLY AUTOMATED MULTI-PUMPING FLOW SYSTEM

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Helena H R Amorim (Autor) Outra; Karine L Marques (Autor) Outra; Joao L M Santos (Autor) FFUP; Jose L F C Lima (Autor) FFUP

Revista

Título: Analytical Letters

Vol. 44 Nº 4

Páginas: 2074-2084

ISSN: 0003-2719

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 5 Citações

ISI Web of Science

Scopus - 8 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química > Química analítica

Outras Informações

ID Authenticus: P-002-X9T

DOI: 10.1080/00032719.2010.546018

Resumo (PT): A flow-based methodology for the spectrophotometric determination of ciprofloxacin and norfloxacin, based on the oxidation with N-bromosuccinimide in acidic medium, was developed. The proposed procedure was implemented in a multi-pumping flow system, which provided excellent mixing conditions due to the pulsed flow produced by solenoid micro-pumps actuation, resulting on a sensitive, simple, fast, and versatile analytical method. Linear calibration plots were obtained for ciprofloxacin and norfloxacin concentrations ranging from 5 to 70 mg L−1 with an R.S.D < 2.2% (n = 10). Detection limits (3σ) were 0.27 mg L−1 and 0.99 mg L−1 for norfloxacin and ciprofloxacin, respectively. <br> <br> <a target="_blank" href="http://www.tandfonline.com/doi/abs/10.1080/00032719.2010.546018 "> Texto integral </a> <br> <br>

Abstract (EN): A flow-based methodology for the spectrophotometric determination of ciprofloxacin and norfloxacin, based on the oxidation with N-bromosuccinimide in acidic medium, was developed. The proposed procedure was implemented in a multi-pumping flow system, which provided excellent mixing conditions due to the pulsed flow produced by solenoid micro-pumps actuation, resulting on a sensitive, simple, fast, and versatile analytical method. Linear calibration plots were obtained for ciprofloxacin and norfloxacin concentrations ranging from 5 to 70 mg L(-1) with an R.S.D < 2.2% (n=10). Detection limits (3 sigma) were 0.27 mg L(-1) and 0.99 mg L(-1) for norfloxacin and ciprofloxacin, respectively.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11