Resumo (PT):
A mechanized system for the determination of β–blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.
<br>
<br>
Keywords: beta-blockers, sequential injection analysis, SIA, spectrophotometry, pharmaceutical formulations
<br>
<a target="_blank" href="http://jbcs.sbq.org.br/jbcs/2008/vol19_n3/26-07396AR.pdf"> Texto integral </a>
<br>
<br>
Abstract (EN):
A mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these Substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1 acebutolol (32.85 - 140 mg U) and propranolol (16.58 - 120 mg U). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.
Idioma:
Inglês
Tipo (Avaliação Docente):
Científica
Nº de páginas:
6