Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2024

Autores

Tavares, V (Autor) Outra; Marques, IS (Autor) Outra; de Melo, IG (Autor) Outra; Assis, J (Autor) Outra; Pereira, D (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: International Journal Of Molecular Sciences

Vol. 25

Página Final: 1845

ISSN: 1661-6596

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00Z-ZVR

DOI: 10.3390/ijms25031845

Abstract (EN): Ovarian cancer (OC) is the female genital malignancy with the highest lethality. Patients present a poor prognosis mainly due to the late clinical presentation allied with the common acquisition of chemoresistance and a high rate of tumour recurrence. Effective screening, accurate diagnosis, and personalised multidisciplinary treatments are crucial for improving patients' survival and quality of life. This comprehensive narrative review aims to describe the current knowledge on the aetiology, prevention, diagnosis, and treatment of OC, highlighting the latest significant advancements and future directions. Traditionally, OC treatment involves the combination of cytoreductive surgery and platinum-based chemotherapy. Although more therapeutical approaches have been developed, the lack of established predictive biomarkers to guide disease management has led to only marginal improvements in progression-free survival (PFS) while patients face an increasing level of toxicity. Fortunately, because of a better overall understanding of ovarian tumourigenesis and advancements in the disease's (epi)genetic and molecular profiling, a paradigm shift has emerged with the identification of new disease biomarkers and the proposal of targeted therapeutic approaches to postpone disease recurrence and decrease side effects, while increasing patients' survival. Despite this progress, several challenges in disease management, including disease heterogeneity and drug resistance, still need to be overcome.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 28