Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Pereira, R (Autor) Outra; Silva, AMS (Autor) Outra; Ribeiro, D (Autor) Outra; Silva, VLM (Autor) Outra; Eduarda Fernandes (Autor) FFUP

Revista

Título: European Journal of Medicinal Chemistry

Vol. 252

ISSN: 0223-5234

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-68E

DOI: 10.1016/j.ejmech.2023.115280

Abstract (EN): Chalcones are bioactive molecules of natural and synthetic sources, whose physicochemical properties, reac-tivity, and biological activities are well-known among the scientific community. However, there are many molecules strictly related to chalcones with significantly less recognition like bis-chalcones. Several studies indicated that bis-chalcones have advantages over chalcones in specific bioactivities like anti-inflammatory activity.This review article describes the chemical structure and chemical properties of bis-chalcones, as well as the methods reported in the literature for the synthesis of these compounds highlighting the most recent de-velopments. Finally, the anti-inflammatory activity of bis-chalcones is described, emphasizing the active struc-tures found in literature and their mechanisms of action.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22