Pluronic (R) triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

de Castro, KC (Autor) Outra; Coco, JC (Autor) Outra; dos Santos, EM (Autor) Outra; Ataide, JA (Autor) Outra; Martinez, RM (Autor) Outra; do Nascimento, MHM (Autor) Outra; Prata, J (Autor) Outra; da Fonte, PRML (Autor) Outra; Severino, P (Autor) Outra; Mazzola, PG (Autor) Outra; Baby, AR (Autor) Outra; Souto, EB (Autor) FFUP; de Araujo, DR (Autor) Outra; Lopes, AM (Autor) Outra

Revista

Título: Journal of Controlled Release

Vol. 353

Páginas: 802-822

ISSN: 0168-3659

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00X-N5F

DOI: 10.1016/j.jconrel.2022.12.017

Abstract (EN): This paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to inno-vative examples for improving tumor cytotoxicity while reducing side effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 21