Hydrophilic Polymers for Modified-Release Nanoparticles: A Review of Mathematical Modelling for Pharmacokinetic Analysis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Andreani, T (Autor) Outra; Fangueiro, JF (Autor) Outra; Jose, S (Autor) Outra; Santini, A (Autor) Outra; Silva, AM (Autor) Outra; Souto, EB (Autor) Outra

Revista

Título: Current Pharmaceutical Design

Vol. 21

Páginas: 3090-3096

ISSN: 1381-6128

Editora: Bentham

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 25 Citações

Outras Informações

ID Authenticus: P-00G-DZF

Abstract (EN): Hydrophilic polymers are the most common group of polymers used in the preparation of modified-release drug delivery systems. This is due to their versatility, low cost, high production yield, as well as easy manufacturing and adequate in vitro/in vivo correlation. In normal physiological conditions, the matrix controls the release of the loaded drug over time through a process of diffusion and/or erosion of the matrix, depending on its physicochemical composition. This is particularly relevant when describing the pharmacokinetic profile of nanosized drug delivery systems (nanoparticles). The use of mathematical models became an important tool to characterize the pharmacokinetics of drugs loaded in nanoparticles to improve the drug bioavailability and to establish bioequivalence. Therefore, the drug release profile can be predicted by a minimum number of experimental studies, since the mathematical equations reveal the dissolution rate of the drug loaded in the hydrophilic matrix. The present paper discusses the use of mathematical models when developing modified-release drug delivery systems of nanometer size composed of hydrophilic polymers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7