Lipid nanoemulsions for anti-cancer drug therapy

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2011

Autores

Souto, EB (Autor) Outra; Nayak, AP (Autor) Outra; Murthy, RSR (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: PHARMAZIE

Vol. 66

Páginas: 473-478

ISSN: 0031-7144

Editora: GOVI-VERLAG GMBH

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 25 Citações

Outras Informações

ID Authenticus: P-002-PZQ

DOI: 10.1691/ph.2011.0392

Abstract (EN): Multifunctional lipid nanoemulsions have shown to combine several advantages e.g. tissue targeting, cell targeting, imaging analysis, barrier permeability enhancement, and therapeutic purposes. Depending on the choice of lipid composition, surfactants and additional surface modifiers ratio, different drug loadings may be achieved and exploited for drug delivery in cancer chemotherapy. However, a safe and effective delivery system for cancer therapy should also be able to overcome the major impediment of multidrug resistance. Several strategies have been tested in nanoemulsions including P-glycoprotein-mediated drug resistance. The present review focuses on a comprehensive discussion of the use of nanoemulsions in anti-cancer therapy, reporting the technological aspects of pharmaceutical formulation of these carriers, and exploiting their advantages in siRNA therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6