Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Gouveia, MJ (Autor) Outra; Santos, J (Autor) Outra; Brindley, PJ (Autor) Outra; Rinaldi, G (Autor) Outra; Lopes, C (Autor) Outra; Santos, LL (Autor) Outra; Correia da Costa, JMC (Autor) Outra; Nuno Vale (Autor) FCUP

Revista

Título: Cancer Letters

Vol. 359

Páginas: 226-232

ISSN: 0304-3835

Editora: Elsevier

Indexação

ISI Web of Knowledge - 40 Citações

Scopus - 43 Citações

Outras Informações

ID Authenticus: P-00A-6KF

DOI: 10.1016/j.canlet.2015.01.018

Abstract (EN): An estrogen-DNA adduct mediated pathway may be involved in the pathogenesis of the squamous cell carcinoma of the bladder associated with infection with the blood fluke Schistosoma haematobium. Extracts from developmental stages of S. haematobium, including eggs, induce tumor-like phenotypes in cultured cells. In addition, estrogen-derived, reactive metabolites occur in this pathogen and in sera of infected persons. Liquid chromatography-mass spectrometry analysis was performed on urine from 40 Angolans diagnosed with urogenital schistosomiasis (UGS), half of who also presented UGS-associated squamous cell carcinoma and/or urothelial cell carcinoma. The analysis revealed numerous estrogenlike metabolites, including seven specifically identified in UGS cases, but not reported in the database of metabolites in urine of healthy humans. These schistosome infection-associated metabolites included catechol estrogen quinones (CEQ) and CEQ-DNA-adducts, two of which had been identified previously in S. haematobium. In addition, novel metabolites derived directly from 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG) were identified in urine of all 40 cases of UGS. These metabolites can be expected to provide deeper insights into the carcinogenesis UGS-induced bladder cancer, and as biomarkers for diagnosis and/or prognosis of this neglected tropical disease-linked cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7