p A simple electrochemical detection of atorvastatin based on disposable screen-printed carbon electrodes modified by molecularly imprinted polymer: Experiment and simulation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Rebelo, P (Autor) Outra; Pacheco, JG (Autor) Outra; Voroshylova, IV (Autor) FCUP; Andre Melo (Autor) FCUP; Natalia N D S Cordeiro (Autor) FCUP; Delerue Matos, C (Autor) Outra

Revista

Título: Analytica Chimica Acta

Vol. 1194

ISSN: 0003-2670

Editora: Elsevier

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 10 Citações

Outras Informações

ID Authenticus: P-00V-ZE2

DOI: 10.1016/j.aca.2021.339410

Abstract (EN): Atorvastatin (ATV) is a statin member consumed in high quantities worldwide. In response to that, the occurrence of ATV in environmental waters has become a reality, highlighting the need of rapid and sensitive analytical devices for its monitoring. In this work, the first electrochemical molecularly imprinted polymer (MIP) sensor for the detection of ATV in water samples is presented. Computational studies were conducted based on quantum mechanical (QM) calculations and molecular dynamics (MD) simulations for rational selection of a suitable functional monomer and to study in detail the templatemonomer interaction, respectively. The sensor was prepared by electropolymerisation of the selected 4aminobenzoic acid (ABA) monomer with ATV, acting as template, on screen printed carbon electrode (SPCE). Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques were applied to characterise the modified electrode surfaces. The quantitative measurements were carried out with differential pulse voltammetry (DPV) in 0.1 M phosphate buffer (pH = 7). After investigation and optimisation of important experimental parameters, a linear working range down to 0.05 mmol L-1 was determined with a correlation coefficient of 0.9996 and a limit of detection (LOD) as low as 0.049 mmol L-1 (S/N = 3). High sensitivity and selectivity of the prepared sensor were demonstrated with the ability to recognise ATV molecules over its closer structural analogues. Moreover, the sensor was quickly and successfully applied in spiked water samples, proving its potential for future on-site monitoring of ATV in environmental waters.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11