The Crossroads between Infection and Bone Loss

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Oliveira, TC (Autor) Outra; Gomes, MS (Autor) ICBAS; Gomes, AC (Autor) Outra

Revista

Título: Microorganisms

Vol. 8

Páginas: 1-18

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00T-1KN

DOI: 10.3390/microorganisms8111765

Abstract (EN): Bone homeostasis, based on a tight balance between bone formation and bone degradation, is affected by infection. On one hand, some invading pathogens are capable of directly colonizing the bone, leading to its destruction. On the other hand, immune mediators produced in response to infection may dysregulate the deposition of mineral matrix by osteoblasts and/or the resorption of bone by osteoclasts. Therefore, bone loss pathologies may develop in response to infection, and their detection and treatment are challenging. Possible biomarkers of impaired bone metabolism during chronic infection need to be identified to improve the diagnosis and management of infection-associated osteopenia. Further understanding of the impact of infections on bone metabolism is imperative for the early detection, prevention, and/or reversion of bone loss. Here, we review the mechanisms responsible for bone loss as a direct and/or indirect consequence of infection.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18