Chronic consumption of the dietary polyphenol chrysin attenuates metabolic disease in fructose-fed rats

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Andrade, N (Autor) Outra; Andrade, S (Autor) Outra; Silva, C (Autor) Outra; Rodrigues, I (Autor) Outra; Guardao, L (Autor) Outra; guimaraes, jt (Autor) FMUP; Elisa Keating (Autor) FMUP; Martel, F (Autor) FMUP

Revista

Título: European Journal of Nutrition

Vol. 59

Páginas: 151-165

ISSN: 1436-6207

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 22 Citações

Outras Informações

ID Authenticus: P-00Q-41F

DOI: 10.1007/s00394-019-01895-9

Abstract (EN): Purpose Metabolic syndrome (MS) is a major public health issue worldwide and fructose consumption has been associated with MS development. Recently, we showed that the dietary polyphenol chrysin is an effective inhibitor of fructose uptake by human intestinal epithelial cells. Therefore, our aim was to investigate if chrysin interferes with the development of MS induced by fructose in an animal model. Methods Adult male Sprague-Dawley rats (220-310 g) were randomly divided into four groups: (A) tap water (control), (B) tap water and a daily dose of chrysin (100 mg/kg) by oral administration (chrysin) (C) 10% fructose in tap water (fructose), and (D) 10% fructose in tap water and a daily dose of chrysin (100 mg/kg) by oral administration (fructose + chrysin). All groups were fed ad libitum with standard laboratory chow diet and dietary manipulation lasted 18 weeks. Results Fructose-feeding for 18 weeks induced an increase in serum triacylglycerols, insulin and angiotensin II levels and in hepatic fibrosis and these changes did not occur in fructose + chrysin rats. Moreover, the increase in both systolic and diastolic blood pressure which was found in fructose-fed animals from week 14th onwards was not observed in fructose + chrysin animals. In contrast, the increase in energy consumption, liver/body, heart/body and right kidney/body weight ratios, serum proteins, serum leptin and liver triacylglycerols observed in fructose-fed rats was not affected by chrysin. Conclusions Chrysin was able to protect against some of the MS features induced by fructose-feeding.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15