The role of salivary peptides in dental caries

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

vitorino, r (Autor) Outra; lobo, mjc (Autor) Outra; duarte, jr (Autor) FADEUP; ferrer-correia, aj (Autor) Outra; domingues, pm (Autor) Outra; amado, fml (Autor) Outra

Revista

Título: Biomedical Chromatography

Vol. 19 Nº 2

Páginas: 214-222

ISSN: 0269-3879

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 62 Citações

Scopus - 72 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-000-3XQ

DOI: 10.1002/bmc.438

Abstract (EN): Dental caries is a complex disease, characterized by demineralization of tooth structure. With a protective role, several salivary phosphopeptides appear to be involved in remineralization processes, delaying the loss of tooth structure. In this work we have correlated peptide saliva composition with dental caries susceptibility through the analysis of saliva and hydroxyapatite-adsorbed salivary peptides samples. Saliva samples were obtained from two groups, a caries-free and a caries-susceptible group, and were analysed using HPLC-MS and a sequential extraction with 6 M of guanidine followed by trifluoroacetate. Data analysis has allowed us to verify a strong correlation between large amounts phosphopeptides (PRP1/3, histatin 1 and statherin), and the absence of dental caries, which reinforces the importance of these peptides in the maintenance of tooth integrity. In addition, in the caries-susceptible group a high number of peptide fragments was observed, suggesting a high proteolytic activity. Copyright (c) 2004 John Wiley D Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9