Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

da Silva, LP (Autor) FCUP; Magalhaes, CM (Autor) Outra; Nunez Montenegro, A (Autor) Outra; Ferreira, PJO (Autor) Outra; Duarte, D (Autor) Outra; Rodriguez Borges, JE (Autor) FCUP; Nuno Vale (Autor) ICBAS; Joaquim C G E Esteves da Silva (Autor) FCUP

Revista

Título: Biomolecules

Vol. 9 Nº 9

Página Final: 384

ISSN: 2218-273X

Editora: MDPI

Indexação

ISI Web of Knowledge - 30 Citações

Scopus - 28 Citações

Outras Informações

ID Authenticus: P-00R-1BY

DOI: 10.3390/biom9080384

Abstract (EN): Cancer is a very challenging disease to treat, both in terms of treatment efficiency and side-effects. To overcome these problems, there have been extensive studies regarding the possibility of improving treatment by employing combination therapy, and by exploring therapeutic modalities with reduced side-effects (such as photodynamic therapy (PDT)). Herein, this work has two aims: (i) to develop self-activating photosensitizers for use in light-free photodynamic therapy, which would eliminate light-related restrictions that this therapy currently possesses; (ii) to assess their co-treatment potential when combined with reference chemotherapeutic agents (Tamoxifen and Metformin). We synthesized three new photosensitizers capable of self-activation and singlet oxygen production via a chemiluminescent reaction involving only a cancer marker and without requiring a light source. Cytotoxicity assays demonstrated the cytotoxic activity of all photosensitizers for prostate and breast tumor cell lines. Analysis of co-treatment effects revealed significant improvements for breast cancer, producing better results for all combinations than just for the individual photosensitizers and even Tamoxifen. By its turn, co-treatment for prostate cancer only presented better results for one combination than for just the isolated photosensitizers and Metformin. Nevertheless, it should be noted that the cytotoxicity of the isolated photosensitizers in prostate tumor cells was already very appreciable.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14