Exposure assessment of Portuguese population to multiple mycotoxins: The human biomonitoring approach

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Martins, C (Autor) Outra; Vidal, A (Autor) Outra; De Boevre, M (Autor) Outra; De Saeger, S (Autor) Outra; Nunes, C (Autor) Outra; Torres, Duarte (Autor) FCNAUP; Goios, A (Autor) Outra; Lopes, C (Autor) Outra; Assunção, R (Autor) Outra; Alvito, P (Autor) Outra

Revista

Título: International Journal of Hygiene and Environmental Health

Vol. 222

Páginas: 913-925

ISSN: 1438-4639

Editora: Elsevier

Indexação

ISI Web of Knowledge - 53 Citações

Scopus - 58 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00Q-RJ1

DOI: 10.1016/j.ijheh.2019.06.010

Abstract (EN): Mycotoxins constitute a relevant group of food contaminants with several associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring studies have been globally developed to assess the exposure to mycotoxins at individual level. In order to overcome this lack of data, the present study concerned the analysis of mycotoxins in 24h urine and first-morning urine paired samples from 94 participants enrolled within the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015¿2016). Following a salt-assisted matrix extraction, urine samples were analysed by liquid chromatography¿mass spectrometry for the simultaneous determination of 37 urinary mycotoxins¿ biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. Alternariol was identified for the first time in urine samples from a European country; however, risk characterization was not performed due to lack of reference intake value. These results confirmed mycotoxins as part of the human exposome of the Portuguese population reinforcing the need for further studies regarding the determinants of exposure. © 2019 Elsevier GmbH

Idioma: Inglês

Tipo (Avaliação Docente): Científica