LXR alpha and LXR beta Nuclear Receptors Evolved in the Common Ancestor of Gnathostomes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Fonseca, E (Autor) Outra; Ruivo, R (Autor) Outra; Lopes Marques, M (Autor) Outra; Zhang, HX (Autor) Outra; Santos, MM (Autor) FCUP; Venkatesh, B (Autor) Outra; Filipe F C Castro (Autor) FCUP

Revista

Título: Genome Biology and Evolution

Vol. 9

Páginas: 222-230

ISSN: 1759-6653

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 12 Citações

Outras Informações

ID Authenticus: P-00M-JFY

DOI: 10.1093/gbe/evw305

Abstract (EN): Nuclear receptors (NRs) regulate numerous aspects of the endocrine system. They mediate endogenous and exogenous cues, ensuring a homeostatic control of development and metabolism. Gene duplication, loss and mutation have shaped the repertoire and function of NRs in metazoans. Here, we examine the evolution of a pivotal orchestrator of cholesterol metabolism in vertebrates, the liver X receptors (LXRs). Previous studies suggested that LXR alpha and LXR beta genes emerged in the mammalian ancestor. However, we show through genome analysis and functional assay that bona fide LXR alpha and LXR beta orthologues are present in reptiles, coelacanth and chondrichthyans but not in cyclostomes. These findings show that LXR duplicated before gnathostome radiation, followed by asymmetric paralogue loss in some lineages. We suggest that a tighter control of cholesterol levels in vertebrates was achieved through the exploitation of a wider range of oxysterols, an ability contingent on ligand-binding pocket remodeling.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9