Regular voluntary running has favorable histological effects on doxorubicin-induced kidney toxicity in Wistar rats

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Daniela Filipa Cardoso (Autor) Outra; Hans-Joachim Appell Coriolano (Autor) Outra; José Alberto Duarte (Autor) FADEUP

Revista

Título: Cell and Tissue Research

Vol. 374

Páginas: 177-187

ISSN: 0302-766X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Classificação Científica

FOS: Ciências médicas e da saúde ; Ciências sociais

Outras Informações

ID Authenticus: P-00P-KYN

DOI: 10.1007/s00441-018-2840-z

Abstract (EN): Knowing the therapeutic effects of regular physical exercise on kidney toxicity induced by a single dose of doxorubicin (DOX) in animal models, the aim of this study is to verify the effectiveness of regular voluntary running on kidney histology after a prolonged DOX administration, mimicking a chemotherapy protocol. Thirty-four male Wistar rats were randomly divided into two clusters: DOX (n=17) and SSS (sterile saline solution, n=17), receiving a weekly intraperitoneal injection of DOX (2mg/kg) or vehicle for 7weeks, respectively. Two weeks after the last injection, five animals from each cluster (SSSG, n=5; DOXG, n=5) were euthanized, while the remaining ones were divided into sedentary (DOXsed, n=6; SSSsed, n=6) and active subgroups (DOXact, n=6; SSSact, n=6). Active animals were placed individually in cages with a running wheel for regular voluntary activity. After 2months, the animals were euthanized and kidneys were histologically examined. Compared to SSSG, kidneys from DOXG revealed higher levels of damage, more collagen content and thickening of Bowman's capsule (p<.05). The levels of damage and thickness of Bowman's capsule increased in DOXsed as compared to DOXG (p<.05). Compared to DOXsed, the DOXact presented an overall improvement in kidney structure (p<.05), with a decrease in collagen content and of the thickness of Bowman's capsule. The results allow concluding that regular voluntary running attenuate the long-term harmful effects on kidney structure induced by a prolonged DOX treatment. These results, supporting the potential benefit of physical activity in patients under DOX treatment, need to be tested in humans.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11